Cross-family small GTPase ubiquitination by the intracellular pathogen Legionella pneumophila

Abstract excerpt

The intracellular bacterial pathogen Legionella pneumophila ( L.p.) manipulates eukaryotic host ubiquitination machinery to form its replicative vacuole. While nearly 10% of L.p.’s ∼330 secreted effector proteins are ubiquitin ligases or deubiquitinases, a comprehensive measure of temporally resolved changes in the endogenous host ubiquitinome during infection has not been undertaken. To elucidate how L.p....

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