Article

Tranilast for Advanced Heart Failure in Patients with Muscular Dystrophy: A Single-Arm, Open-Label, Multicenter Study

2021-11-29

Abstract excerpt

<title>Abstract</title> <p> <bold>Background:</bold> The transient receptor potential cation channel subfamily V member 2 (TRPV2) is a stretch-sensitive calcium channel. TRPV2 overexpression in the sarcolemma of skeletal and cardiac myocytes causes calcium influx into the cytoplasm, which triggers myocyte degeneration. In animal models of cardiomyopathy and muscular dystrophy (MD), TRPV2 inhibition was effectiv...

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Literature Corpus work: dee7fe09-ffcc-5305-930b-6e88db35b5f5
DOI: 10.21203/rs.3.rs-1090803/v1

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