Article

Structural variants contribute substantially to complex trait heritability

2026-03-03

Abstract excerpt

Despite accumulating evidence that structural variants (SVs) exert disproportionate functional effects, their genome-wide contribution to complex trait heritability has not yet been systematically quantified. Here, we introduce MiXeR-SV, a tool that integrates long-read-derived SVs from existing reference catalogs with genome-wide association summary statistics to quantify SV heritability and enrichment. Applying...

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Literature Corpus work: ded1abd0-88d3-5669-9f85-2aef0400078b
DOI: 10.64898/2026.02.28.708732

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