Interneurons in the subplate are associated with cortical maturation across the foetal human cortex

Abstract excerpt

<title>Abstract</title> <p>GABA is the principle excitatory neurotransmitter of the foetal brain. This early excitatory role is driven by developing GABAergic interneurons, whose spatial distribution and maturation influence regional cortical development. Here, we leveraged brain transcriptomes from human foetal brains to investigate early regional differences in interneuron expression and identify the functional...

Topics

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• Animals, Newborn
• Autistic Disorder
• Cerebral Cortex
• Gene Expression Regulation, Developmental
• Gene Regulatory Networks
• Neonatal and fetal brain pathology
• Organ Specificity
• Protein Interaction Maps

Identifiers and source

Literature Corpus work

de828d19-346e-552a-bf72-7ccd595de7e7

DOI

10.21203/rs.3.rs-10335768/v1