Article

Epigenetics of Muscle- and Brain-Specific Expression of KLHL Family Genes

2020-10-19

Abstract excerpt

KLHL genes and the related KBTBD genes encode components of the Cullin-E3 ubiquitin ligase complex and typically target tissue-specific proteins for degradation, thereby affecting differentiation, homeostasis, metabolism, cell signaling, and the oxidative stress response. Despite their importance in normal cell function and in disease (KLHL40, KLHL41, KBTBD13, KEAP1, and ENC1), previous studies that examined epige...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: de6bb972-3c5b-55b6-9ff5-a76c6f33d2b7
DOI: 10.20944/preprints202010.0365.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Epigenetics of Muscle- and Brain-Specific Expression of KLHL Family GenesDOI 10.20944/preprints202010.0365.v1Read

Epigenetics of skeletal muscle-associated genes in the <i>ASB, LRRC, TMEM</i> , and <i>OSBPL</i> gene familiesSemantic proximity Read

Long-range control of gene expression: emerging mechanisms and disruption in disease.Semantic proximity Read

Characterizing the molecular impact of<i>KMT2D</i>variants on the epigenetic and transcriptional landscapes in Kabuki SyndromeSemantic proximity Read

Hypermethylation of human DNA: Fine-tuning transcription associated with developmentSemantic proximity Read

Leveraging the Mendelian disorders of the epigenetic machinery to systematically map functional epigenetic variation.Semantic proximity Read

N-Terminal Deleted Isoforms of E3 Ligase RNF220 (Isoform 4) Are Ubiquitously Expressed and Required for Mouse Muscle DifferentiationSemantic proximity Read

Characterizing the molecular impact of KMT2D variants on the epigenetic and transcriptional landscapes in Kabuki syndrome.Semantic proximity Read

Pathological LSD1 mutations repress enhancer-mediated gene regulatory networks in early differentiationSemantic proximity Read

Deciphering regulatory networks in the mouse genomeSemantic proximity Read

Co-expression patterns define epigenetic regulators associated with neurological dysfunctionSemantic proximity Read

A genome-wide assessment of conserved SNP alleles reveals a panel of regulatory SNPs relevant to the peripheral nerve.Semantic proximity Read

Epigenomic footprints across 111 reference epigenomes reveal tissue-specific epigenetic regulation of lincRNAs.Semantic proximity Read