Article

Required concentration index quantifies effective drug combinations against hepatitis C virus infection

2020-01-09

Abstract excerpt

<h4>ABSTRACT</h4> Successful clinical drug development requires rational design of combination treatments based on preclinical data. Anti-HCV drugs exhibit significant diversity in antiviral effect. Dose-response assessments can be used to determine parameters profiling the diverse antiviral effect during combination treatment. In the current study, a combined experimental and mathematical approaches were used to...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: de491f96-3099-547f-93f7-a72d11900bec
DOI: 10.1101/2020.01.09.899807

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Required concentration index quantifies effective drug combinations against hepatitis C virus infectionDOI 10.1101/2020.01.09.899807Read

Required concentration index quantifies effective drug combinations against hepatitis C virus infectionSemantic proximity Read

Required concentration index quantifies effective drug combinations against hepatitis C virus infection.Semantic proximity Read

Oral Combination Therapies for Hepatitis C Virus Infection: Successes, Challenges, and Unmet Needs.Semantic proximity Read

Searching for synergy: Identifying optimal antiviral combination therapy using Hepatitis C virus (HCV) agents in a replicon system.Semantic proximity Read

Current therapies for chronic hepatitis C. Drug combination achieves sustained response in more than half of patients.Semantic proximity Read

Treatment of hepatitis C with new fixed dose combinations.Semantic proximity Read

Mathematical modeling of multi-drugs therapy: a challenge for determining the optimal combinations of antiviral drugs.Semantic proximity Read

A Simple but Accurate Method for Evaluating Drug-Resistance in Infectious HCVcc System.Semantic proximity Read

Identification of novel antiviral drug combinations in vitro and tracking their developmentSemantic proximity Read

The IDentif.AI 2.0 Pandemic Readiness Platform: Rapid Prioritization of Optimized COVID-19 Combination Therapy RegimensSemantic proximity Read

Assessment of combined antiviral drug treatment against selected α-, β-, and γ-herpesvirusesSemantic proximity Read

Treatment optimisation for hepatitis C in the era of combination direct-acting antiviral therapy: a systematic review and meta-analysisSemantic proximity Read