Article
Treatment of hepatitis C with new fixed dose combinations.
Expert opinion on pharmacotherapy - 1 Aug 2017
Soriano Vincent, Fernandez-Montero José V, de Mendoza Carmen, Benitez-Gutierrez Laura, Peña José M, Arias Ana, Barreiro Pablo
Abstract excerpt
INTRODUCTION: The advent of oral direct-acting antivirals (DAA) has revolutionized the hepatitis C virus (HCV) therapeutic landscape providing cure rates over 90%. However, a subset of patients remains at higher risk for treatment failure, including those infected with: i) genotype 3 and cirrhosis; ii) resistance-associated substitutions (RAS) occurring either as natural polymorphisms or selected after prior DAA...
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