Translational Potential and Pharmacokinetic Challenges of Procyanidin C1 as a Next-Generation Senotherapeutic Agent

Abstract excerpt

Procyanidin C1 (PCC1), a B-type procyanidin trimer derived from natural sources, has recently garnered significant attention in preclinical models due to its potential to specifically induce apoptosis in senescent cells (senolytic activity) and extend healthspan. However, existing data reveal a pronounced pharmacological paradox: the in vitro induction of apoptosis in senescent cells typically requires high microm...

Topics

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• Aldehyde Dehydrogenase
• Anthracenes
• ATP Binding Cassette Transporter, Subfamily B, Member 1
• ATP Binding Cassette Transporter, Subfamily G, Member 2
• Carcinogenesis
• Mice, SCID
• Skin Protection and Aging
• Telomeres, Telomerase, and Senescence

Identifiers and source

Literature Corpus work

de1ffd2c-a6e7-5c49-ab21-2f8ae6a982a5

DOI

10.20944/preprints202602.1086.v1