Article
Homoharringtonine, a novel senotherapeutic, mitigates diet- and age-associated obesity and insulin resistance
2023-07-19
Abstract excerpt
<title>Abstract</title> <p>The accumulation of senescent cells in white adipose tissue (WAT) is closely associated with the functional decline of WAT and plays a causal role in the pathogenesis of metabolic diseases. Therefore, the elimination of senescent cells in WAT holds promise for the treatment and prevention of age-related metabolic diseases. Using a drug-repositioning strategy for 2,150 clinically applied...
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Identifiers and source
- Literature Corpus work
- 248c191e-597e-5f03-916e-b632dfcd5fc3
- DOI
- 10.21203/rs.3.rs-3147770/v1