Article

Reconstructed human pigmented skin/epidermis models achieve epidermal pigmentation through melanocore transfer

2022-03-04

Abstract excerpt

The skin acts as a barrier to environmental insults and provides many vital functions. One of these is to shield DNA from harmful UV radiation, which is achieved by skin pigmentation arising as melanin is produced and dispersed within the epidermal layer. This is a crucial defence against DNA damage, photo-ageing and skin cancer. The mechanisms and regulation of melanogenesis and melanin transfer involve extensive...

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Literature Corpus work: dddb3c28-0791-58b6-b22b-1bdde512978c
DOI: 10.1101/2022.03.03.482849

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