Back to search

Article

Network Pharmacology Reveals the Potential of Dolastatin 16 as Diabetic Wound Healing Agent

2023-07-31

Abstract excerpt

Dolastatin 16, a marine cyclic depsipeptide, was first isolated from the sea hare Dolabella Auricularia by Pettit et al . Since its bioactivity lacks of information, target identification is the indispensable strategy to reveal the potential target and mechanism of action of Dolastatin 16. Network pharmacology was utilized to identify the target associated with the disease, gene ontology, and KEGG pathway. The res...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
dd47d4df-42f4-5f9f-8356-ee91d05e88f2
DOI
10.21203/rs.3.rs-3204523/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Network Pharmacology Reveals the Potential of Dolastatin 16 as Diabetic Wound Healing AgentDOI 10.21203/rs.3.rs-3204523/v1
Network pharmacology-based investigation of potential targets of Vitamin K2MK7 in treatment of diabetic neuropathySemantic proximity
Identification of compounds to promote diabetic wound healing based on transcriptome signatureSemantic proximity
In-silico evidence of ADAM Metalloproteinase Pathology in Cancer Signalling NetworksSemantic proximity
Integrating bioinformatics and multiple machine learning to identify mitophagy-related targets for the diagnosis and treatment of diabetic foot ulcers: evidence from transcriptome analysis and drug dockingSemantic proximity
SARS-CoV-2 intervened by NSAIDs: A network pharmacology approach to decipher signaling pathway and interactive genesSemantic proximity
Bioinformatics analysis and vivo experiment of Artemisia argyi essential oil for the treatment of pressure ulcer by modulating Wnt/β-catenin pathwaySemantic proximity
Exploring the Therapeutic Potential of Momordica charantia in Targeting Protein Kinase C Delta (PRKCD) for Type 2 Diabetes Mellitus: Insights from Network Pharmacology, Molecular Docking, and Molecular Dynamics SimulationsSemantic proximity
Integrative Bioinformatics Analysis of MicroRNA Networks in Diabetic Foot Ulcer Healing: Structure-Function Relationships and Therapeutic Target IdentificationSemantic proximity
Exploring novel natural compound-based therapies for Duchenne muscular dystrophy management: insights from network pharmacology, QSAR modeling, molecular dynamics, and free energy calculationsSemantic proximity
Revealing the Multi-Target Mechanisms of Fespixon Cream in Diabetic Foot Ulcer Healing: Integrated Network Pharmacology, Molecular Docking, and Clinical RT-qPCR ValidationSemantic proximity
Designing peptide inhibitors targeting LRP6 co-receptor to restrict its association to DKK1; an Alzheimer’s disease therapeutic strategySemantic proximity
In Silico Study on the Interactions, Molecular Docking, Dynamics and Simulation of Potential Compounds from Withania somnifera (L.) Dunal Root against Cancer by Targeting KAT6ASemantic proximity
Select a neighboring publication to make it the new centre.