In-silico evidence of ADAM Metalloproteinase Pathology in Cancer Signalling Networks

Abstract excerpt

<h4>Purpose: </h4> Literature mining portrays major role of ADAM17 in cancer and inflammation, but due to its structural similarity of the catalytic site to that of the MMPs, it is a challenging task to design a candidate drug for targeting ADAM17. Herein, we have exploited the analogues of some existing inhibitors, with an aim at discovering a potent inhibitor, which might be repurposed as a drug against ADAM17 i...

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• Cell Adhesion Molecules Research
• COVID-19 Clinical Research Studies
• HER2/EGFR in Cancer Research
• Monoclonal and Polyclonal Antibodies Research
• Peptidase Inhibition and Analysis
• Protease and Inhibitor Mechanisms
• SARS-CoV-2 and COVID-19 Research
• Signaling Pathways in Disease

Identifiers and source

Literature Corpus work

61d01ec9-9b30-5608-86f7-9c153e9c75a9

DOI

10.22541/au.170666266.69822138/v1