Article

SARS-CoV-2 intervened by NSAIDs: A network pharmacology approach to decipher signaling pathway and interactive genes

2020-11-30

Abstract excerpt

<h4>Background: </h4> Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) showed promising clinical efficacy toward COVID-19 patients as painkillers and anti-inflammatory agents. However, the prospective anti-COVID-19 mechanisms of NSAIDs are not evidently exposed. Therefore, we intended to decipher the most potent NSAIDs candidate(s) and its novel mechanism(s) against COVID-19 by network pharmacology. <h4>Method: </h4...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8e119a43-cdef-54ee-b476-1a5bd86df86e
DOI: 10.21203/rs.3.rs-111615/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

SARS-CoV-2 intervened by NSAIDs: A network pharmacology approach to decipher signaling pathway and interactive genesDOI 10.21203/rs.3.rs-111615/v1Read

Indomethacin: an exploratory study of antiviral mechanism and host-pathogen interaction in COVID-19Semantic proximity Read

Exploring of mechanisms and predicting of potential drugs of the comorbidity between migraine and multiple sclerosis based on bioinformatics analysis of transcriptome dataSemantic proximity Read

Effects of non-steroidal anti-inflammatory drugs and other eicosanoid pathway modifiers on antiviral and allergic responses. EAACI task force on eicosanoids consensus report in times of COVID-19Semantic proximity Read

Discovery of potential drugs for COVID-19 based on the connectivity mapSemantic proximity Read

NSAIDs/Nitazoxanide/Azithromycin Repurposed for COVID-19: Potential Mitigation of the Cytokine Storm Interleukin-6 Amplifier via Immunomodulatory EffectsSemantic proximity Read

In Silico Prediction of Molecular Targets of Astragaloside IV for Alleviation of COVID-19 Hyperinflammation by Systems Network Pharmacology and Bioinformatic Gene Expression AnalysisSemantic proximity Read

Network of “drug-target-SARS-CoV-2 Related Genes” Through Integrated Analysis of Pharmacology and Geo DatabaseSemantic proximity Read

Identification of Genes and Pathways of Nonsteroidal Anti-Inflammatory Drugs Acting on Synovia from Women with Knee Osteoarthritis by Bioinformatics AnalysisSemantic proximity Read

Network Pharmacology Reveals That Resveratrol Can Alleviate COVID-19-Related HyperinflammationSemantic proximity Read

FXR antagonism of NSAIDs contributes to drug-induced liver injury identified by systems pharmacology approach.Semantic proximity Read

Drug-repurposing against COVID-19 by targeting a key signaling pathway: An in silico studySemantic proximity Read

In-silico screening and in-vitro assay show the antiviral effect of Indomethacin against SARS-CoV-2Semantic proximity Read