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Article

Impact of Baloxavir Resistance-Associated Substitutions on Influenza Virus Growth and Drug Susceptibility.

Journal of virology - 27 Jul 2023

Hickerson Brady T, Petrovskaya Svetlana N, Dickensheets Harold, Donnelly Raymond P, Ince William L, Ilyushina Natalia A

Abstract excerpt

Baloxavir marboxil (baloxavir) is a recently FDA-approved influenza virus polymerase acidic (PA) endonuclease inhibitor. Several PA substitutions have been demonstrated to confer reduced susceptibility to baloxavir; however, their impacts on measurements of antiviral drug susceptibility and replication capacity when present as a fraction of the viral population have not been established. We generated recombinant...

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Share to Amino Acid Substitution
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37404185
DOI: 10.1128/jvi.00154-23
PMCID: PMC10373543

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