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Susceptibility of widely diverse influenza a viruses to PB2 polymerase inhibitor pimodivir

10 Feb 2021

Abstract excerpt

values determined by HINT were similar for both subtypes of seasonal viruses, A(H1N1)pdm09 and A(H3N2), across three seasons. Human seasonal viruses with PB2 substitutions S324C, S324R, or N510K displayed a 27-317-fold reduced pimodivir susceptibility by HINT. In addition, pimodivir was effective at inhibiting replication of a diverse group of animal-origin viruses that have pandemic potential, including avian...

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PMID: 33581212
DOI: 10.1016/j.antiviral.2021.105035

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