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Emergence of the novel PA-D27G mutation conferring reduced baloxavir susceptibility in influenza A viruses circulating in China, 2018-2025.

Emerging microbes & infections - 1 Dec 2026

Sun Binhuang, Sun Yulei, Wang Hongyu, Tang Xiaolu, Tang Wanggang, Mi Yabo, Shen Zhouying, Xue Quanlin, Lu Yinying, Zhao Xiaoyu, Ai Jingwen, Lu Jian, Zhang Wenhong

Abstract excerpt

Seasonal influenza A viruses evolve rapidly, yet the emergence and molecular basis of resistance to the polymerase acidic (PA) inhibitor baloxavir marboxil (BXM), which is widely used in China, remain elusive. To address this, 3938 PA gene sequences were collected from influenza patients across mainland China between 2018 and 2025, from the national surveillance network and GISAID. By screening post-market...

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Influenza A virus
Influenza, Human
Morpholines
Oxazines
Pyridines

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

RNA-Dependent RNA Polymerase

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PMID: 41555529
DOI: 10.1080/22221751.2026.2620222
PMCID: PMC12865856

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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