Article

Understanding the role of RBR-E3 ligase in regulation of cellular homeostasis in human malaria parasite

2024-03-15

Abstract excerpt

E3 ligases constitute an important component of proteostasis machinery which plays a critical role in the survival of malaria parasite through post-translational modifications of its proteinsubstrates. In contrast to humans, parasite E3 ligases have not been extensively studied. Here, we characterize a unique Plasmodium E3 ligase that has both RING and HECT-like features with zinc-coordinating domains. Plasmodium...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9eb5479e-0193-568d-8374-8b67160b4b45
DOI: 10.22541/au.168866515.52639160/v2

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Understanding the role of RBR-E3 ligase in regulation of cellular homeostasis in human malaria parasiteDOI 10.22541/au.168866515.52639160/v2Read

<i>Plasmodium falciparum</i> contains functional SCF and CRL4 ubiquitin E3 ligases, and CRL4 is critical for cell division and membrane integritySemantic proximity Read

The Skp1-Cullin1-FBXO1 complex is a pleiotropic regulator required for the formation of gametes and motile forms in Plasmodium bergheiSemantic proximity Read

Drug resistance-associated mutations in <i>Plasmodium</i> UBP-1 disrupt ubiquitin hydrolysisSemantic proximity Read

Targeting the Plasmodium Ubiquitin/Proteasome System with Anti- Malarial Compounds: Promises for the FutureSemantic proximity Read

Nedd8 hydrolysis by UCH proteases in Plasmodium parasitesSemantic proximity Read

Mammalian deubiquitinating enzyme inhibitors display <i>in vitro</i> and <i>in vivo</i> activity against malaria parasites and potentiate artemisinin actionSemantic proximity Read

Proximity interaction analysis of the <i>Plasmodium falciparum</i> putative ubiquitin ligase <i>Pf</i> RNF1 reveals a role in RNA regulationSemantic proximity Read

Drug resistance-associated mutations in Plasmodium UBP-1 disrupt its essential deubiquitinating activity.Semantic proximity Read

Unraveling the Ubiquitome of the Human Malaria ParasiteSemantic proximity Read

From Drosophila to Human: Biological Function of E3 Ligase Godzilla and Its Role in DiseaseSemantic proximity Read

The D113N mutation in the RING E3 ubiquitin protein ligase gene is not associated with ex vivo susceptibility to common anti-malarial drugs in African Plasmodium falciparum isolates.Semantic proximity Read

The Plasmodium falciparum RING Finger Protein PfRNF1 Forms an Interaction Network with Regulators of Sexual DevelopmentSemantic proximity Read