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Article

Orchestrating osteogenic differentiation of mesenchymal stem cells—identification of placental growth factor as a mechanosensitive gene with a pro-osteogenic role

29 Jul 2013

Abstract excerpt

Skeletogenesis is initiated during fetal development and persists through adult life as either a remodeling process in response to homeostatic regulation or as a regenerative process in response to physical injury. Mesenchymal stem cells (MSCs) play a crucial role providing progenitor cells from which osteoblasts, bone matrix forming cells are differentiated. The mechanical environment plays an important role in...

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PMID: 23897668
DOI: 10.1002/stem.1482

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