Article

Stratification of Risk of Progression to Colectomy in Ulcerative Colitis using Measured and Predicted Gene Expression

2021-04-04

Abstract excerpt

<h4>SUMMARY</h4> An important goal of clinical genomics is to be able to estimate the risk of adverse disease outcomes. Between 5% and 10% of ulcerative colitis (UC) patients require colectomy within five years of diagnosis, but polygenic risk scores (PRS) utilizing findings from GWAS are unable to provide meaningful prediction of this adverse status. By contrast, in Crohn’s disease, gene expression profiling of...

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Literature Corpus work: dcd5b5a2-2ffb-5744-aee1-80e7fc69735f
DOI: 10.1101/2021.04.02.438187

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