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Modeling the Role of a Flexible Loop and Active Site Side Chains in Hydride Transfer Catalyzed by Glycerol-3-Phosphate Dehydrogenase

2020-06-25

Abstract excerpt

Glycerol-3-phosphate dehydrogenase is a biomedically important enzyme that plays a crucial role in lipid biosynthesis. It is activated by a ligand-gated conformational change that is necessary for the enzyme to reach a catalytically competent conformation capable of efficient transition state stabilization. While the human form (hlGPDH) has been the subject of extensive structural and biochemical studies, corr...

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Literature Corpus work
dca2fa0d-f3ff-525d-8e5f-3f547921ca68
DOI
10.26434/chemrxiv.12550868.v1
Open publication

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