Article

Updated Testing Sensitivities and Variants of Uncertain Significance in CanRisk

2026-07-23

Abstract excerpt

<title>Abstract</title> <p>Background The CanRisk platform provides breast, ovarian and prostate cancer risk predictions on the basis of multiple risk factors including germline variants in nine cancer susceptibility genes. Predictions are dependent on assumptions about the sensitivity of genetic testing and how variants of uncertain significance (VUS) are handled. Methods We propose updated default sensitiviti...

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Literature Corpus work: dc8b0d0b-7892-53f8-a346-4e4f4340a3aa
DOI: 10.21203/rs.3.rs-10342247/v1

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