Article

Expansion of KRAS hot spot mutations reactive T cells from human pancreatic tumors using autologous T-cells as the antigen-presenting cells

2022-08-16

Abstract excerpt

Adoptive cell therapy (ACT) with expanded Tumor-infiltrating lymphocytes (TIL) or TCR gene-modified T cells (TCR-T) that recognize mutant KRAS neo-antigens can mediate tumor regression in patients with advanced pancreatic ductal adenocarcinoma (PDAC) (1 2) . The mutant KRAS targeted ACT holds great potential to achieve durable clinical responses for PDAC, which has had no meaningful improvement over 40 years. Howe...

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Literature Corpus work: dc3695b4-58bf-584e-8da6-3bf130cdfc9c
DOI: 10.21203/rs.3.rs-1944651/v1

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