IND-Enabling Studies for a TCR-T Targeting a Pancreatic Cancer KRASG12V Mutation

Abstract excerpt

PURPOSE: To develop adoptive T-cell therapy with genetically engineered T-cell receptor (TCR; TCR-T) that recognizes the KRASG12V mutation, we performed an Investigational New Drug (IND)-enabling preclinical study of a new TCR (051). This TCR was isolated from a patient with pancreatic ductal adenocarcinoma with the KRASG12V mutation that could be presented by the HLA-A*11:01 allele, the most common allele of the...

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