Article

Group sequential designs using early outcomes in the R package gsearly: implementation and application in randomized clinical trials

2026-03-26

Abstract excerpt

<title>Abstract</title> <p> <bold>Background</bold> : Group sequential clinical trials are widely used for the design of randomized clinical trials as they offer the possibility of stopping a study early for either treatment efficacy or futility. A common feature of many such designs is that the main study outcome is observed at a number of fixed occasions during participant follow-up with inferences being made...

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Literature Corpus work: dc05f4e3-a43e-51de-9e99-4f7859c3adeb
DOI: 10.21203/rs.3.rs-9158358/v1

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