Article

Transcription factor SP1-Mediated Upregulation of B-Myb Promotes Glioma Aggression Through Transcriptomic Mechanism

2025-10-08

Abstract excerpt

<title>Abstract</title> <p> <bold>Background</bold> Given the limited therapeutic options for gliomas, identifying molecules with therapeutic potential remains critical. This study aimed to investigate the functional significance and regulatory mechanisms of B-Myb in glioma progression. <bold>Methods</bold> B-Myb expression was assessed in glioma tissues through multimodal analyses (qRT-PCR, Western blotting,...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: daced011-4dbf-58f5-a879-d8ed9cc22451
DOI: 10.21203/rs.3.rs-7699276/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Transcription factor SP1-Mediated Upregulation of B-Myb Promotes Glioma Aggression Through Transcriptomic MechanismDOI 10.21203/rs.3.rs-7699276/v1Read

Transcription Factors with Targeting Potential in Gliomas.Semantic proximity Read

PAXIP1-AS2 is a Promising Target for Glioma Progression and TreatmentSemantic proximity Read

Transcriptional factor specificity protein 1 (SP1) promotes the proliferation of glioma cells by up-regulating midkine (MDK)Semantic proximity Read

Association between B‑Myb proto‑oncogene and the development of malignant tumors (Review)Semantic proximity Read

HMGB2 is a biomarker associated with poor prognosis promoting radioresistance in glioma by targeting base excision repair pathwaySemantic proximity Read

Long non-coding RNA PAXIP1-AS1 facilitates cell invasion and angiogenesis of glioma by recruiting transcription factor ETS1 to upregulate KIF14 expressionSemantic proximity Read

Prognostic Significance of mRNA Expression RBBP8 or its Methylation in GliomasSemantic proximity Read

Downregulation of BASP1 Promotes Temozolomide Resistance in Gliomas via Epigenetic Activation of the FBXO32/NF-κB/MGMT AxisSemantic proximity Read

BRD4/H3K27Ac Epigenetic Reprogramming Orchestrates Chemotherapy-induced Polyploid Giant Cancer Cells and Glioma ProgressionSemantic proximity Read

Transcription Factor FOXK1 Regulates the lncRNA NEAT1 to Promote Glioma Development Through Mediating KDM3ASemantic proximity Read

An HLA-G/SPAG9/STAT3 axis promotes brain metastasesSemantic proximity Read

MiR-4310 induced by SP1 targets PTEN to promote glioma progressionSemantic proximity Read