Article

Zoledronate reduces loading-induced microdamage in cortical ulna of ovariectomized rats

2023-05-14

Abstract excerpt

As a daily physiological mechanism in bone, microdamage accumulation dissipates energy and helps to prevent fractures. However, excessive damage accumulation might bring adverse effects to bone mechanical properties, which is especially problematic among the osteoporotic and osteopenic patients treated by bisphosphonates. Some pre-clinical studies in the literature applied forelimb loading models to produce well-c...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: daad4e32-e42f-5014-8d6b-7424d25368c6
DOI: 10.1101/2023.05.12.540579

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Zoledronate reduces loading-induced microdamage in cortical ulna of ovariectomized ratsDOI 10.1101/2023.05.12.540579Read

Adaptive and injury response of bone to mechanical loadingSemantic proximity Read

Developing and Investigating a Nanovibration Intervention for the Prevention/Reversal of Bone Loss Following Spinal Cord InjurySemantic proximity Read

Pulsed Electromagnetic Fields Improve Bone Microstructure and Strength in Ovariectomized Rats through a Wnt/Lrp5/β-Catenin Signaling-Associated MechanismSemantic proximity Read

Fatigue Microdamage as an Essential Element of Bone Mechanics and BiologySemantic proximity Read

Bone mechanoregulation allows subject-specific load estimation based on time-lapsed micro-CT and HR-pQCT <i>in vivo</i>Semantic proximity Read

Bone remodeling is regulated by inner ear vestibular signals.Semantic proximity Read

Non-Steroidal Anti-Inflammatory Drugs and Bone Healing in Animal Models – A Systematic Review and Meta-analysisSemantic proximity Read

Establishing Biomechanical Mechanisms in Mouse Models: Practical Guidelines for Systematically Evaluating Phenotypic Changes in the Diaphyses of Long BonesSemantic proximity Read

Perspective on post-menopausal osteoporosis: establishing an interdisciplinary understanding of the sequence of events from the molecular level to whole bone fracturesSemantic proximity Read

Naproxen impairs load-induced bone formation, reduces bone toughness, and delays stress fracture repair in miceSemantic proximity Read

Increased trabecular bone and improved biomechanics in an osteocalcin-null rat model created by CRISPR/Cas9 technology.Semantic proximity Read

Effect of load reduction on the calcification of rat tibial tuberosity: Focus on calcification factors and chondrocyte mechanosensorsSemantic proximity Read