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Article

Transcriptome and epigenome diversity and plasticity of muscle stem cells following transplantation.

PLoS genetics - 1 Oct 2020

Evano Brendan, Gill Diljeet, Hernando-Herraez Irene, Comai Glenda, Stubbs Thomas M, Commere Pierre-Henri, Reik Wolf, Tajbakhsh Shahragim

Abstract excerpt

Adult skeletal muscles are maintained during homeostasis and regenerated upon injury by muscle stem cells (MuSCs). A heterogeneity in self-renewal, differentiation and regeneration properties has been reported for MuSCs based on their anatomical location. Although MuSCs derived from extraocular muscles (EOM) have a higher regenerative capacity than those derived from limb muscles, the molecular determinants that...

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Identifiers

PMID: 33125370
DOI: 10.1371/journal.pgen.1009022
PMCID: PMC7657492

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