Article

The Hyaluronan Synthase isoforms direct distinct patterns of fibroblast activation linked to fibrosis progression versus resolution following renal ischaemia

2024-03-29

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> The stroma plays a key role during renal development and in regeneration after injury. However, following injury, the stroma expands driving progressive fibrosis. Hyaluronan (HA) is a glycosaminoglycan that is absent in healthy kidney stroma but highly expressed in disease. To understand strategies to modulate stromal HA towards therapeutic advantage, this study compares HA...

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Literature Corpus work: da8e89bf-b6c6-5190-8521-ea09f3e355fb
DOI: 10.1101/2024.03.27.586996

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