Article

Cactin is essential for G1 progression in Toxoplasma gondii

2012-04-09

Abstract excerpt

Summary Toxoplasma gondii is an obligate intracellular protozoan parasite whose rapid lytic replication cycles define its pathogenicity. We identified a temperature‐sensitive growth mutant, FV‐P6, which irreversibly arrests before the middle of the G1 stage of the tachyzoite cell cycle. This arrest is caused by a point mutation in a gene conserved across eukaryotes, Cactin, whose product localizes to the nucleus....

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Literature Corpus work: da0a6796-c2d9-567d-80a7-6dfbeb27ae33
DOI: 10.1111/j.1365-2958.2012.08044.x

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