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Article

Porcine reproductive and respiratory syndrome virus (PRRSV) up-regulates IL-15 through PKCβ1-TAK1-NF-κB signaling pathway.

Virology - 1 Sept 2016

Du Li, Liu Yihao, Du Yinping, Wang Honglei, Zhang Meijie, Du Yijun, Feng Wen-Hai

Abstract excerpt

Porcine reproductive and respiratory syndrome (PRRS) caused by PRRS virus (PRRSV) is one of the most important infectious diseases in swine industry. IL-15 is a pleiotropic cytokine and has been shown to be essential to transform NKs, CD8 T cells, and other cells of the immune systems into functional effectors. Here, we demonstrated that the broad-spectrum or conventional PKC inhibitors repressed PRRSV-induced...

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PMID: 27318153
DOI: 10.1016/j.virol.2016.06.007

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MAVS

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