Article

Global Genomic Surveillance Reveals Pre-EUA Fixation of Pemivibart (VYD2311) Escape Constellations in SARS-CoV-2

2025-12-23

Abstract excerpt

Pemivibart (VYD222) and its successor, VYD2311, target a shared, evolutionarily vulnerable epitope in the SARS-CoV-2 spike receptor-binding domain (RBD). Although VYD2311 an IND features an Fc-mediated half-life extension and demonstrates a reported 17-fold increase in in vitro neutralization potency over pemivibart (marketed as Pemgarda™, VYD222), both antibodies engage identical contact residues - R346, K444, F4...

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Literature Corpus work: d992b7f9-69e3-5c1b-8915-1b9b9f74c9bd
DOI: 10.20944/preprints202512.2013.v1

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