Article

Global Genomic Surveillance Reveals Pre-EUA Fixation of Pemivibart (VYD2311) Escape Constellations in SARS-CoV-2

2026-01-06

Abstract excerpt

Pemivibart (VYD222) and its successor, VYD2311, target a shared, evolutionarily vulnerable epitope in the SARS-CoV-2 spike receptor-binding domain (RBD). Although VYD2311 an IND features an Fc-mediated half-life extension and demonstrates a reported 17-fold increase in in-vitro neutralization potency over pemivibart (marketed as Pemgarda™, VYD222), both antibodies engage identical contact residues such as R346, K4...

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Literature Corpus work: cd537e25-4195-5dab-9afc-93004168933b
DOI: 10.20944/preprints202512.2013.v2

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