Genomic determinants of antibiotic resistance for Helicobacter pylori treatment: a retrospective phenotypic and genotypic observational study.

doi:10.1016/j.lanmic.2025.101217

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Topics Community

Back to search

Article

Genomic determinants of antibiotic resistance for Helicobacter pylori treatment: a retrospective phenotypic and genotypic observational study.

The Lancet. Microbe - 1 Jan 2026

Martínez-Martínez Francisco José, Chiner-Oms Álvaro, Furió Victoria, Yamaoka Yoshio, Dekker John P, Mégraud Francis, Bénéjat Lucie, Ducournau Astrid, Giese Alban, Jehanne Quentin, Jauvain Marine, Camargo M Constanza, Comas Iñaki, Lehours Philippe

Abstract excerpt

BACKGROUND: Rising antimicrobial resistance of Helicobacter pylori is a public health challenge. Genomic-based susceptibility testing allows for the identification of resistance-associated mutations, complementing conventional diagnostics and advancing towards pathogen-based personalised therapies. Our study aimed to identify genes and mutations involved in antimicrobial resistance in H pylori and evaluate the...

Topics

Helicobacter pylori
Anti-Bacterial Agents
Clarithromycin
Humans
Retrospective Studies
Microbial Sensitivity Tests
Levofloxacin
Genotype
Helicobacter Infections

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

RNA, Ribosomal, 23S

Phenotype

Drug Resistance, Bacterial

Mutation

DNA Gyrase

Genome, Bacterial

Genomics

Source

Open in PubMed Open full text

Identifiers

PMID: 41453373
DOI: 10.1016/j.lanmic.2025.101217
PMCID: PMC12961094

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genomic determinants of antibiotic resistance for Helicobacter pylori treatment: a retrospective phenotypic and genotypic observational study.PMID 41453373Read ↗

Genomic Analysis of Antimicrobial Resistance Genotype-to-Phenotype Agreement in Helicobacter pyloriSemantic proximity Read ↗

Genomic analysis of Helicobacter pylori in Australia: Antimicrobial resistance, phylogenetic patterns, and virulence factors.Semantic proximity Read ↗

Identification of genetic determinants of antibiotic resistance in Helicobacter pylori isolates in Vietnam by high-throughput sequencingSemantic proximity Read ↗

Whole Genome Sequencing for Studying Helicobacter pylori Antimicrobial ResistanceSemantic proximity Read ↗

Helicobacter pylori Infections in the Bronx, New York: Surveying Antibiotic Susceptibility and Strain Lineage by Whole-Genome Sequencing.Semantic proximity Read ↗

A Survey of Helicobacter pylori Antibiotic-Resistant Genotypes and Strain Lineages by Whole-Genome Sequencing in China.Semantic proximity Read ↗

[The application of genotypic resistance testing for clarithromycin and levofloxacin in different types of Helicobacter pylori infected patients based on gastric mucosal samples].Semantic proximity Read ↗

Whole genome sequencing reveals novel genetic mutations of Helicobacter pylori associating with resistance to clarithromycin and levofloxacin.Semantic proximity Read ↗

Genetic Determinants and Prediction of Antibiotic Resistance Phenotypes in Helicobacter pyloriSemantic proximity Read ↗

Evaluation of Antibiotic Resistance of Helicobacter pylori Strains Isolated in Bari, Southern Italy, in 2017-2018 by Phenotypic and Genotyping Methods.Semantic proximity Read ↗

Phenotypic and genotypic analysis of Helicobacter pylori resistance patterns, molecular characteristics, and CYP2C19 polymorphisms in Nanjing: a retrospective cross-sectional study.Semantic proximity Read ↗

Helicobacter pylori resistance in Hainan Province, China: investigating phenotypes and genotypes through whole-genome sequencing.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.