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A pharmacometric grey zone reconciles high metronidazole resistance rates with bismuth quadruple therapy efficacy in <i>Helicobacter pylori</i>

2026-06-23

Abstract excerpt

<h4>Summary</h4> <h4>Background</h4> Metronidazole (MET) resistance in Helicobacter pylori ( H. pylori ) exceeds 50–60% globally, yet MET-containing bismuth quadruple therapy (BQT) achieves >90% eradication in MET-resistant infections. We hypothesise this discordance stems from a structural limitation of two-fold dilution: a pharmacometric grey zone between the 128 and 256 µg/mL breakpoints where treatable iso...

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Literature Corpus work
52d683d1-5804-5fb9-a9b0-8deeab182737
DOI
10.64898/2026.06.21.26356170
Open publication

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