Article

A genome-wide genetic pleiotropy approach identified shared loci between multiple system atrophy and inflammatory bowel disease

2019-08-31

Abstract excerpt

<h4>ABSTRACT</h4> We aimed to identify shared genetic background between multiple system atrophy (MSA) and autoimmune diseases by using the conjFDR approach. Our study showed significant genetic overlap between MSA and inflammatory bowel disease and identified DENND1B, C7 , and RSP04 loci, which are linked to significant changes in methylation or expression levels of adjacent genes. We obtained evidence of enri...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d8935970-5a59-50b3-9587-601b54d97372
DOI: 10.1101/751354

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A genome-wide genetic pleiotropy approach identified shared loci between multiple system atrophy and inflammatory bowel diseaseDOI 10.1101/751354Read

Shared Genetics of Multiple System Atrophy and Inflammatory Bowel DiseaseSemantic proximity Read

Combining genetic mapping with genome-wide expression in experimental autoimmune encephalomyelitis highlights a gene network enriched for T cell functions and candidate genes regulating autoimmunity.Semantic proximity Read

Inflammatory Bowel Disease and Neurodegenerative Disorders: Integrated Evidence from Mendelian Randomization, Shared Genetic Architecture and TranscriptomicsSemantic proximity Read

Genome-wide Pleiotropy Between Parkinson Disease and Autoimmune Diseases.Semantic proximity Read

Unveiling Shared Genetic Architectures and Causality: Intestinal Diseases and Neurological Diseases.Semantic proximity Read

Genetic overlap between Parkinson’s disease and inflammatory bowel diseaseSemantic proximity Read

Investigating Causality and Shared Genetic Architecture between Neurodegenerative Disorders and Inflammatory Bowel DiseaseSemantic proximity Read

Genetic overlap between Parkinson disease and inflammatory bowel diseaseSemantic proximity Read

Disrupted long-range gene regulations elucidate shared tissue-specific mechanisms of neuropsychiatric disorders.Semantic proximity Read

Inflammatory bowel disease and Parkinson's disease: common pathophysiological links.Semantic proximity Read

Investigating the shared genetic architecture between multiple sclerosis and inflammatory bowel diseases.Semantic proximity Read

Mapping the comorbid landscape of Parkinson’s disease and Crohn’s disease along the gut-blood-brain axisSemantic proximity Read