Article

<i>In vitro</i> to <i>in vivo</i> pharmacokinetic translation guidance

2022-09-27

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Pharmacokinetics (PK), exposure profiles and doses of candidate drugs in man are commonly predicted using data produced using various in vitro methods, such as hepatocytes (for intrinsic metabolic clearance (CL int )), plasma (for unbound fraction (f u )), Caco-2 (measuring apparent permeability (P app ) for prediction of in vivo fraction absorbed (f a )) and plasma wa...

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Literature Corpus work: d88bf468-cb7e-5946-b8da-03a7299552c8
DOI: 10.1101/2022.09.26.509470

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