Article

Methylation status, mRNA and protein expression of the SMAD4 gene in patients with non-melanocytic skin cancers

2023-04-10

Abstract excerpt

<title>Abstract</title> <p><bold>Background</bold> SMAD4 is a potent tumor suppressor. SMAD4 loss increases genomic instability and plays a critical role in the DNA damage response that leads to skin cancer development. We aimed to investigate SMAD4 methylation effects on mRNA and protein expression of SMAD4 in cancer and healthy tissues from patients with basal cell carcinoma (BCC), cutaneous squamous cell carci...

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Literature Corpus work: d879cdd9-490a-5724-abd2-b0d3f004b1f6
DOI: 10.21203/rs.3.rs-2751602/v1

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