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Qishen Granule Protects against Doxorubicin‐Induced Cardiotoxicity by Coordinating MDM2‐p53‐Mediated Mitophagy and Mitochondrial Biogenesis

1 Jan 2022

Abstract excerpt

Doxorubicin (DOX), the anthracycline chemotherapeutic agent, is widely used for the treatment of various cancers. However, its clinical application is compromised by dose‐dependent and fatal cardiotoxicity. This study is aimed at investigating the cardioprotective effects of Qishen granule (QSG) and the specific mechanism by which QSG alleviates DOX‐induced cardiotoxicity (DIC) and providing an alternative for...

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PMID: 36120600
DOI: 10.1155/2022/4344677

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