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MicroRNAs in anthracycline cardiotoxicity: biomarkers, mechanisms, and therapeutic advances

22 Aug 2025

Abstract excerpt

Background: Anthracycline-based chemotherapy is a highly effective treatment for numerous cancers, yet its clinical use is severely limited by cumulative, dose-dependent cardiotoxicity. MicroRNAs (miRNAs), as key post-transcriptional regulators of gene expression, play a pivotal role in the pathophysiology of cardiovascular disease, but their specific functions in anthracycline-induced cardiotoxicity (AIC)...

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PMID: 40918193
DOI: 10.3389/fcvm.2025.1614878

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