Structurally Informed Fitness Landscapes for Surveillance of Emerging PRRSV Variants

Abstract excerpt

<h4>ABSTRACT</h4> Antibodies play a central role in neutralizing pathogens through direct interference with viral entry and recruitment of effector immune cells. However, viruses employ sophisticated escape mechanisms to evade these defenses, primarily through mutations in surface glycoproteins that reduce antibody binding affinity or alter critical functional domains. Antibody escape remains a formidable challen...

Topics

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• Amino Acid Substitution
• Bayes Theorem
• Computational Biology
• Evolution, Molecular
• Immune Evasion
• Porcine respiratory and reproductive syndrome virus
• Software
• Viral Envelope Proteins

Identifiers and source

Literature Corpus work

d80ddae8-600b-5b9c-88e6-178524231f7f

DOI

10.1101/2025.10.06.680729