Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Coordinated gene expression within sustained STAT3‐associated chromatin conformations contributes to hepatocellular carcinoma progression

26 Jul 2025

Abstract excerpt

BACKGROUND: Phosphorylated signal transducer and activator of transcription 3 (p-STAT3) has emerged as a critical modulator of hepatocellular carcinoma (HCC) progression. However, its role in three-dimensional (3D) chromatin conformation and the expression of genes linked to HCC aggressiveness remains largely unexplored. This study aimed to identify HCC 3D chromatin conformations that are regulated by sustained...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Mechanisms and Therapy
Share to Cytokine Signaling Pathways and Interactions
Share to Hepatocellular Carcinoma Treatment and Prognosis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 40715029
DOI: 10.1002/cac2.70049

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Coordinated gene expression within sustained STAT3‐associated chromatin conformations contributes to hepatocellular carcinoma progressionPMID 40715029Read ↗

STAT3 Targets Suggest Mechanisms of Aggressive Tumorigenesis in Diffuse Large B-Cell LymphomaSemantic proximity Read ↗

Integrative analysis based on ATAC-seq and RNA-seq reveals a novel oncogene PRPF3 in hepatocellular carcinomaSemantic proximity Read ↗

The cell cycle state defines TACC3 as a regulator gene in glioblastomaSemantic proximity Read ↗

Methylation silencing of SOCS-3 promotes cell growth and migration by enhancing JAK/STAT and FAK signalings in human hepatocellular carcinomaSemantic proximity Read ↗

A new role for STAT3 as a regulator of chromatin topologySemantic proximity Read ↗

Overexpression of WAVE3 promotes tumor invasiveness and confers an unfavorable prognosis in human hepatocellular carcinomaSemantic proximity Read ↗

Erlotinib induces 3D genome rearrangements in lung cancer cells activating tumor suppressor genes through FOXA2-bound EpromotersSemantic proximity Read ↗

Activation of STAT3 Signal Pathway Correlates with Twist and E-Cadherin Expression in Hepatocellular Carcinoma and Their Clinical SignificanceSemantic proximity Read ↗

STAT3 suppresses transcription of proapoptotic genes in cancer cells with the involvement of its N-terminal domainSemantic proximity Read ↗

Epigenetic Dysregulation of the Expression of PRSS3 Splice Variants Increases the Heterogeneity of Transcripts and Functionality in Human Hepatocellular CarcinomaSemantic proximity Read ↗

The Transcriptional Regulator Sin3A Contributes to the Oncogenic Potential of STAT3Semantic proximity Read ↗

Thyroid hormone suppresses expression of stathmin and associated tumor growth in hepatocellular carcinomaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.