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Third generation cephalosporin-induced L-form transition in <i>Shigella sonnei</i> reveals a virulence-survival trade-off underlying persistent infection

2025-07-17

Abstract excerpt

Shigellosis remains a major global health burden, and the increasing prevalence of multidrug-resistant (MDR) Shigella strains is complicating effective antibiotic therapy. Bacteria may survive antibiotics by transitioning into cell wall-deficient L-forms, which are intrinsically resistant to β-lactams and can revert to a virulent state, potentially causing relapsing infections. Here we characterized a clinical MD...

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Identifiers and source

Literature Corpus work
d7da05ac-e727-5c1f-be00-0581c9404d0b
DOI
10.1101/2025.07.17.665312
Open publication

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Third generation cephalosporin-induced L-form transition in <i>Shigella sonnei</i> reveals a virulence-survival trade-off underlying persistent infectionDOI 10.1101/2025.07.17.665312
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