Dissecting the molecular evolution of fluoroquinolone-resistant Shigella sonnei.

doi:10.1038/s41467-019-12823-0

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Article

Dissecting the molecular evolution of fluoroquinolone-resistant Shigella sonnei.

Nature communications - 23 Oct 2019

Chung The Hao, Boinett Christine, Pham Thanh Duy, Jenkins Claire, Weill Francois-Xavier, Howden Benjamin P, Valcanis Mary, De Lappe Niall, Cormican Martin, Wangchuk Sonam, Bodhidatta Ladaporn, Mason Carl J, Nguyen To Nguyen Thi, Ha Thanh Tuyen, Voong Vinh Phat, Duong Vu Thuy, Nguyen Phu Huong Lan, Turner Paul, Wick Ryan, Ceyssens Pieter-Jan, Thwaites Guy, Holt Kathryn E, Thomson Nicholas R, Rabaa Maia A, Baker Stephen

Abstract excerpt

Shigella sonnei increasingly dominates the international epidemiological landscape of shigellosis. Treatment options for S. sonnei are dwindling due to resistance to several key antimicrobials, including the fluoroquinolones. Here we analyse nearly 400 S. sonnei whole genome sequences from both endemic and non-endemic regions to delineate the evolutionary history of the recently emergent fluoroquinolone-resistant...

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PMID: 31645551
DOI: 10.1038/s41467-019-12823-0
PMCID: PMC6811581

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