Article

Andrographolide Causes p53-independent HCC Cell Death through p62 Accumulation and Impaired DNA Damage Repair

2023-03-10

Abstract excerpt

Hepatocellular carcinoma (HCC) is a deadly cancer, with the dominant driver mutations such as p53 yet undruggable. There is urgent demand to search for novel agents and therapeutic targets for HCC treatment. Andrographolide (Andro, a clinical-available anti-inflammation phytochemical agent) could inhibit different types of cancer including HCC, but the molecular mechanisms involved are yet unclear. The present stu...

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Literature Corpus work: d7cdd2dd-a05e-5eb9-9ff2-9e6df0605aff
DOI: 10.22541/au.167844940.05342281/v1

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