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Insight into the role of p62 in the cisplatin resistant mechanisms of ovarian cancer

16 Apr 2020

Abstract excerpt

Cisplatin is a platinum-based first-line drug for treating ovarian cancer. However, chemotherapy tolerance has limited the efficacy of cisplatin for ovarian cancer patients. Research has demonstrated that cisplatin causes changes in cell survival and death signaling pathways through its interaction with macromolecules and organelles, which indicates that investigation into the DNA off-target effects of cisplatin...

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PMID: 32322174
DOI: 10.1186/s12935-020-01196-w

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