Article

Comparative Effects of Tamoxifen on NLRP3 Inflammasome Activation and IL-1β Secretion in Obese and Non-Obese Horses with Asthma

2026-08-21

Abstract excerpt

Equine asthma is a chronic neutrophilic airway disease that can be exacerbated by obesity, an immunometabolic condition increasingly linked to activation of the NLRP3 inflammasome and the release of interleukin-1 beta (IL-1β). Tamoxifen, a selective oestrogen receptor modulator with immunomodulatory properties independent of its hormonal action, has previously been shown to reduce neutrophilic airway inflammation...

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Literature Corpus work: d75d30b3-1442-5783-ae56-aa387c58c0a7
DOI: 10.20944/preprints202608.1521.v1

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