Article

Isoflavones impair response to anti-PD1 therapy in murine breast cancer models, irrespective of dietary fiber and fecal short chain fatty acid levels

2025-12-09

Abstract excerpt

<h4>Background</h4> Fermentable dietary fibers, also called microbiota-accessible carbohydrates (MAC), and the consequent increase in fecal short-chain fatty acids (SCFAs) are linked to improved responsiveness to immune checkpoint blockade (ICB) therapy in human and mouse studies. However, experimental diets high in MAC also often contain estrogenic isoflavones, which may counter fiber’s beneficial effects by cau...

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Literature Corpus work: d759f4be-fe8d-553d-af2c-601c8028a440
DOI: 10.64898/2025.12.05.692375

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