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Chronotherapy as a Potential Strategy to Reduce Ifosfamide-Induced Encephalopathy: A Preclinical Study in a Murine Model

2025-09-03

Abstract excerpt

<h4>Purpose</h4> Nearly five decades after its introduction into clinical oncology, ifosfamide (IFO) remains a widely used alkylating chemotherapeutic agent for the treatment of sarcomas, germ-cell tumors and selected hematological malignancies in both adult and pediatric oncology. Its use is limited by severe toxicities, particularly hemorrhagic cystitis and central nervous system complications. Recent studies h...

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Literature Corpus work
d7293c7c-b5f1-5307-b164-4bd087112c6b
DOI
10.1101/2025.08.28.672634
Open publication

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