Article

Seasonal and Vitamin D3 mediated methylome reprogramming of peripheral immune cells and anti-viral responses

2025-12-29

Abstract excerpt

Seasonality of inflammatory and infectious diseases is associated with several factors, including serum vitamin D fluctuations and immunological state. We longitudinally investigated peripheral blood mononuclear cell (PBMC) methylomes of healthy South African adults in summer, winter, and after high-dose winter vitamin D 3 supplementation to determine whether vitamin D 3 modulates seasonal epigenetic variations...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d6fb3b87-616f-5aca-bfe1-9b4ad81500b5
DOI: 10.64898/2025.12.22.25342836

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Seasonal and Vitamin D3 mediated methylome reprogramming of peripheral immune cells and anti-viral responsesDOI 10.64898/2025.12.22.25342836Read

A Review: Highlighting the Links between Epigenetics, COVID-19 Infection, and Vitamin DSemantic proximity Read

Vitamins D2 and D3 Have Overlapping But Different Effects on the Human Immune System Revealed Through Analysis of the Blood TranscriptomeSemantic proximity Read

Vitamin D Signaling in the Context of Innate Immunity: Focus on Human MonocytesSemantic proximity Read

Methylation of the Vitamin D Receptor (VDR) Gene, Together with Genetic Variation, Race, and Environment Influence the Signaling Efficacy of the Toll-Like Receptor 2/1-VDR PathwaySemantic proximity Read

Methylation of the Vitamin D Receptor (VDR) gene in human disordersSemantic proximity Read

The applicability of DNA methylation-based tools in a low-income, sub-Saharan African population: Malawi longitudinal study of families and healthSemantic proximity Read

Race/Ethnicity-Specific Association of Vitamin D and Global DNA Methylation: Cross-Sectional and Interventional FindingsSemantic proximity Read

A methylation clock model of mild SARS‐CoV‐2 infection provides insight into immune dysregulationSemantic proximity Read

High-dose vitamin D3 reduces deficiency caused by low UVB exposure and limits HIV-1 replication in urban Southern Africans.Semantic proximity Read

DNA methylation changes in metabolic and immune-regulatory pathways in blood and lymph node CD4 + T cells in response to SIV infectionsSemantic proximity Read

Seasonal Effects on Gene ExpressionSemantic proximity Read

Influence of Vitamin D Status and Vitamin D3 Supplementation on Genome Wide Expression of White Blood Cells: A Randomized Double-Blind Clinical TrialSemantic proximity Read