Methylation of the Vitamin D Receptor (VDR) Gene, Together with Genetic Variation, Race, and Environment Influence the Signaling Efficacy of the Toll-Like Receptor 2/1-VDR Pathway

Abstract excerpt

Background. The disparity in prevalence of infectious diseases across the globe is common knowledge. VDR-mediated TLR2/1 signaling produce antimicrobial peptides which is critical as a first line of defense in innate immunity. Numerous studies disclosed the independent role of genetic polymorphisms in this pathway, vitamin D status or season and more recently epigenetics, as factors contributing to infectious...

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